Cks1 Mediates Vascular Smooth Muscle Cell Polyploidization
نویسندگان
چکیده
منابع مشابه
Platelet factor 4 mediates vascular smooth muscle cell injury responses.
Activated platelets release many inflammatory molecules with important roles in accelerating vascular inflammation. Much is known about platelet and platelet-derived mediator interactions with endothelial cells and leukocytes, but few studies have examined the effects of platelets on components of the vascular wall. Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to ...
متن کاملAkt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization.
Vascular smooth muscle cells (VSMCs) at capacitance arteries of hypertensive individuals and animals undergo marked age- and blood pressure-dependent polyploidization and hypertrophy. We show here that VSMCs at capacitance arteries of rat models of hypertension display high levels of Akt1/PKB protein and activity. Gene transfer of Akt1 to VSMCs isolated from a normotensive rat strain was suffic...
متن کاملCyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.
BACKGROUND Oxidative stress, generated by excessive reactive oxygen species, promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20-kDa chaperone protein secreted from vascular smooth muscle cells (VSMCs) in response to reactive oxygen species that stimulates VSMC proliferation and inflammatory cell migration in vitro; however, the role CyPA plays in vascular function in vivo remains unk...
متن کاملEndoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading
OBJECTIVE Endoglin, a transforming growth factor-β superfamily coreceptor, is predominantly expressed in endothelial cells and has essential roles in vascular development. However, whether endoglin is also expressed in vascular smooth muscle cells (VSMCs), especially in vivo, remains controversial. Furthermore, the roles of endoglin in VSMC biology remain largely unknown. Our objective was to e...
متن کاملCorrection to: Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.
In the article by Tian et al, “Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading,” which published online ahead of print April 27, 2017 (doi: 10.1161/ATVBAHA.116.308859), a correction was needed. The authors have changed the Open Access license type from CC-BY to CC-BY-NC-ND. The change is reflected in this issue and is available at http://at...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m005059200